Stuart A. Kornfeld, MD received the 2022 Roscoe O. Brady Award for Innovation and Accomplishment
Stuart A. Kornfeld, MD, is the David C. and Betty Farrell Professor of Medicine at Washington University in St. Louis. He is best known for his contributions to the field of glycoprotein research – the study of how sugars are attached to proteins and the roles these molecules play in cellular function. His lab was instrumental in elucidating the pathway for the biosynthesis of the Mannose 6-phosphate moieties on lysosomal hydrolases. These residues serve as recognition molecules for the delivery of newly synthesized hydrolases to lysosomes. Defects in this pathway give rise to the lysosomal diseases mucolipidosis II and III. This glycoprotein receptor-mediated uptake of enzymes is the basis for ‘cross-correction’, the underpinning mechanism of all lysosomal enzyme replacement therapies.
Dr. Kornfeld is a graduate of Dartmouth College and received his MD degree from Washington University. He did postgraduate training at Barnes Hospital and later at the National Institutes of Health. He has received numerous awards for his research contributions, including the E.B. Wilson Medal from the American Society for Cell Biology, the Passano Award and the Kober Medal from the Association of American Physicians. He is an elected member of the National Academy of Sciences, the National Academy of Medicine and the American Academy of Arts and Sciences.
The 2022 Roscoe O. Brady Award was presented on Monday, February 7, 2022 at 7:30 AM PST, followed by a scientific presentation from Dr. Kornfeld Dissecting the Mannose 6-Phosphate Pathway – A Key to Understanding Lysosomal Enzyme Trafficking.