3rd Annual Robert J. Gorlin Symposium
Beyond the Blood Brain Barrier:
Strategies for Treating the CNS
Course Director: Jeanine R. Jarnes, PharmD, MSc, BCOP, BCPS
February 6, 2024
5:15 – 7:30 PM

The Annual Robert J. Gorlin Symposium honors the work of Robert James Gorlin, DDS, PhD. Dr. Gorlin was a geneticist, maxillofacial pathologist, and academician at the University of Minnesota School of Dentistry. Spanning over 50 years, his groundbreaking research in genetic disorders of the head and neck revolutionized the understanding of the morphology of lysosomal diseases and many other genetic disorders.
Overview
Each year, WORLDSymposium identifies an unmet need, or critical topic for presentation and discussion in the Annual Robert J. Gorlin Symposium. For 2024, this 2.25-hour non-CE session will discuss current approaches for treating the central nervous system in lysosomal diseases. Presentations will include an overview of current and future approaches for treating the central nervous system, and address challenges in identifying and implementing meaningful outcome measures for evaluating efficacy of central nervous system therapies.
The short-term mission of this session is to provide a broad, sweeping overview (“10,000-foot view”, or possibly even 30,000-foot view) of the current landscape for treating the central nervous system in lysosomal diseases, thereby giving a broad general impression of the current status of CNS treatments.
The long-term mission of this session is to set the stage for future, regularly-held meetings or workshops on this very topic. These future meetings will be designed for more in-depth coverage of key components, as well as generating white papers and creating a platform that will provide ongoing updates, and consensus-based levels of evidence.
Course Director:
Jeanine R. Jarnes, PharmD, MSc, BCOP, BCPS
Assistant Professor, Department of Pediatrics
Pharmacotherapy for Inherited Metabolic Diseases
Advanced Therapies Department
College of Pharmacy, Experimental and Clinical Pharmacology
University of Minnesota
Minneapolis, MN, USA
Co-Chairs:
Robert G. Thorne, PhD
Denali Fellow
Head, Denali Postdoc Program
Denali Therapeutics, South San Francisco, CA
Adjunct Associate Professor, Department of Pharmaceutics
University of Minnesota-Twin Cities, Minneapolis, MN
President, International Brain Barriers Society,
Editorial Board Member, Fluids & Barriers of the CNS
Elsa G. Shapiro, PhD, ABPP
Professor of Pediatrics and Neurology, Division of Pediatric Behavioral Neuroscience
University of Minnesota, Minneapolis, MN
Managing Partner at Shapiro Neuropsychology Consulting, LLC
Faculty and Agenda coming soon.